Biochemical Data: Hazelnut and Cor a 9

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BIOCHEMICAL INFORMATION for Hazelnut

Allergen Name:

Cor a 9

Alternatve Allergen Names:

Corylin, 11S globulin

Allergen Designation:

Major

Protein Family:

11S seed storage globulin, cupin, Pfam PF00190

Sequence Known?:

Yes

Allergen accession No.s:

http://ca.expasy.org/cgi-bin/niceprot.pl?Q8W1C2

3D Structure Accession No.:

Not determined

Calculated Masses:

59127 Da

Experimental Masses:

35-40 kDa (the acidic subunit)

Oligomeric Masses:

360 kDa

Allergen epitopes:

Not known but the acid subunit has been identified as the main IgE binding region.

Allergen stability:
Process, chemical, enzymatic

Not known but likely to be thermostable like other 11S seed storage globulins.

Nature of main cross-reacting proteins:

Not known

Allergen properties & biological function:

Cor a 9 is probably a hexameric seed storage protein. Subunits are synthesised as a precursor which is cleaved into two disulphide linked subunits of approximately 20 kDa and 40 kDa, before forming the hexamer.

Allergen purification:

None reported

Other biochemical information:

Beyer et al. (2002) [670] used two 2 peptide sequences from the 40 kDa band, QGQQQFGQR and HFYLAGNPDDEHQR, to determine the sequence Q8W1C2. The N-terminal sequence from Pastorello et al. (2002) [671] matches that from residues 23-37 of sequence Q8W1C2 with two changes.

References (2)

Beyer K, Grishina G, Bardina L, Grishin A, Sampson HA.
Identification of an 11S globulin as a major hazelnut food allergen in hazelnut-induced systemic reactions J Allergy Clin Immunol. 110(3):517-523 2002
PUBMED ID: 12209105

[670]

Pastorello EA, Vieths S, Pravettoni V, Farioli L, Trambaioli C, Fortunato D, Luttkopf D, Calamari M, Ansaloni R, Scibilia J, Ballmer-Weber BK, Poulsen LK, Wutrich B, Hansen KS, Robino AM, Ortolani C, Conti A
Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol. 109(3):563-570 2002
PUBMED ID: 11898007

[671]

This record was last modified on 18-Oct-2006
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