Biochemical Data: Egg (hen's egg) and Apovitellenin I

View General Food data
View Clinical data
View Biochemical data for:

BIOCHEMICAL INFORMATION for Egg (hen's egg)

Allergen Name:

Apovitellenin I

Alternatve Allergen Names:

Vitellenin, very low density lipoprotein II

Allergen Designation:

Minor

Protein Family:

Very low density lipoprotein family. Pfam PF05418; Apo-VLDL-II.

Sequence Known?:

Yes

Allergen accession No.s:

http://us.expasy.org/cgi-bin/niceprot.pl?P02659

3D Structure Accession No.:

N/A

Calculated Masses:

11966 Da (precursor) 9330.86 Da (mature)

Experimental Masses:

9.5 kDa (reduced)

Oligomeric Masses:

Disulfide-linked homodimer. A tetramer is also observed at neutral pH.

Allergen epitopes:

Not known

Allergen stability:
Process, chemical, enzymatic

Not known

Nature of main cross-reacting proteins:

Not known

Allergen properties & biological function:

Protein component of the very low density lipoprotein found in egg yoke. A potent lipoprotein lipase inhibitor, preventing the loss of triglycerides. As the quail homologue has no intermolecular disulphide, this may not be required for function.

Allergen purification:

George et al. (1987) [1243] and Nimpf et al. (1988) [1535] report a purification of very low density lipoprotein II (apovitellenin I).

Other biochemical information:

Homologous proteins from other birds (quail, turkey and duck) have more than 70% sequence identity and IgE cross-reactivity is likely.

References (4)

George R, Barber DL, Schneider WJ.
Characterization of the chicken oocyte receptor for low and very low density lipoproteins. J Biol Chem. 262(35):16838-16847. 1987
PUBMED ID: 3119592

[1243]

MacLachlan I, Steyrer E, Hermetter A, Nimpf J, Schneider WJ.
Molecular characterization of quail apolipoprotein very-low-density lipoprotein II: disulphide-bond-mediated dimerization is not essential for inhibition of lipoprotein lipase. Biochem J. 317 ( Pt 2):599-604. 1996
PUBMED ID: 8713091

[1134]

Nimpf J, George R, Schneider WJ.
Apolipoprotein specificity of the chicken oocyte receptor for low and very low density lipoproteins: lack of recognition of apolipoprotein VLDL-II. J Lipid Res. 29(5):657-667. 1988
PUBMED ID: 3411240

[1535]

Walsh BJ, Barnett D, Burley RW, Elliott C, Hill DJ, Howden ME.
New allergens from hen's egg white and egg yolk. In vitro study of ovomucin, apovitellenin I and VI, and phosvitin. Int Arch Allergy Appl Immunol. 87(1):81-86. 1988
PUBMED ID: 3170012

[1215]

This record was last modified on 18-Oct-2006
Page processed in 0.062 seconds