Clinical History
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| Number of Studies: |
|
| Number of Patients: |
|
| Symptoms: |
| Swelling of lips, pruritus, generalized urticaria and dyspnea (Niggemann et al. 2002) [887]. Fah et al. 1995 [889] have reported a case of anaphylaxis after eating lychee fruits. |
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Skin Prick Test |
| Number of Studies: |
|
| Food/Type of allergen: |
| Fresh and canned lychee fruits (Fah et al. 1995) [889] Raw lychee (Niggemann et al. 2002) [887] |
|
Protocol:
(controls, definition of positive etc) |
| Prick to prick (Fah et al. 1995) [889] Positive control used was 10 mg/ml histamine dihydrochloride (wheal size 6 mm) Niggemann et al. 2002) [887] |
|
| Number of Patients: |
| A 23-year-old woman (Fah et al. 1995) [889] A 12-year-old girl (Niggemann et al. 2002) [887] |
|
| Summary of Results: |
| SPT was positive to fresh and canned lychee fruit (wheal size >5 mm) (Fah et al. 1995) [889] A positive skin prick test could be shown to raw lychee (wheal size 11 mm), and latex extract (Niggemann et al. 2002) [887] |
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IgE assay (by RAST, CAP etc) |
| Number of Studies: |
|
| Food/Type of allergen: |
| Extracts from uncooked fruits by a low temperature method (Fah et al. 1995) [889] Commercial extracs (Niggemann et al. 2002) [887] |
|
| IgE protocol: |
| EAST (Fah et al. 1995) [889] CAP (Pharmacia) (Niggemann et al. 2002) [887] |
|
| Number of Patients: |
| A 23-year-old woman (Fah et al. 1995) [889] A 12-year-old girl (Niggemann et al. 2002) [887] |
|
| Summary of Results: |
| Specific IgE could be detected to lychee (EAST class 2) by Fah et al. (1995) [889] No specific IgE could be detected to lychee by Niggemann et al. (2002) [887]. Furthermore, specific IgG to lychee was low (7.8 mg/l) and specific IgG4 was below the detection limit. |
|
Immunoblotting |
| Immunoblotting separation: |
| Lychee proteins were separated on 13% homogeneous gel and 5% stacking acrylamidegels under reducing conditions (Fah et al. 1995) [889] Method not described by Niggemann et al. (2002) [887] |
|
| Immunoblotting detection method: |
| The proteins were transferred onto 0.2 µm of nitrocellulose membranes using a semi-dry electroblotting device. The nitrocellulose membrane was incubated with patient sera. IgE antibody detection was performed with peroxidase-conjugated anti-human IgE (Fah et al. 1995). Method not described by Niggemann et al. (2002) [887] |
|
| Immunoblotting results: |
| An immunoblot using an extract of raw lychee showed no reaction to lychee, but a strong response to the latex allergen Hev b 7 (Niggemann et al. 2002) [887]. Serum IgE from a single patient recognised two bands of 16 and 43 kDa (Fah et al. 1995) [889] |
|
Oral provocation |
| Number of Studies: |
|
| Food used and oral provocation
vehicle |
| Raw lychee (Niggemann et al. 2002) [887] |
|
| Blind? |
| No (Niggemann et al. 2002) [887] |
|
| Number of Patients? |
| A 12-year-old girl (Niggemann et al. 2002) [887] |
|
| Dose response |
|
| Symptoms |
| Upon a titrated oral provocation no symptoms were noted within 1 h with a quarter raw lychee fruit. However, after eating half a lychee the patient developed restlessness, flush, generalized urticaria and inspiratory stridor after 50 min. (Niggemann et al. 2002) [887] |
|
IgE cross-reactivity and Polysensitisation |
| Cross-reactivity with latex (Niggemann et al. 2002) [887] Immunoblot inhibition results indicated a 16 kDa allergen as the cross-reactive protein between birch pollen, celery and lychee (Fah et al. 1995) [889] Wellhausen et al. 1996 [888] and Vieths et al. 1998 [886] identified an IgE-binding 35-kDa protein from birch pollen (Bet v 5) with cross-reacting homologs in various plant foods, including lychee. |
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Other Clinical information |
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Reviews (0)
References (4)
Fah J, Wuthrich B, Vieths S
Anaphylactic reaction to lychee fruit: evidence for sensitization to profilin Clin Exp Allergy. 25(10):1018-23. 1995
PUBMED ID:
8556556 |
[889] |
|
Niggemann B, Reibel S, Hipler C, Wahn U
Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex? Pediatr Allergy Immunol. 13(1):64-7 2002
PUBMED ID:
12000501 |
[887] |
|
Vieths S, Frank E, Scheurer S, Meyer HE, Hrazdina G, Haustein D
Characterization of a new IgE-binding 35-kDa protein from birch pollen with cross-reacting homologues in various plant foods Scand J Immunol. 47(3):263-72 1998
PUBMED ID:
9519865 |
[886] |
|
Wellhausen A, Schoning B, Petersen A, Vieths S
IgE binding to a new cross-reactive structure: a 35 kDa protein in birch pollen, exotic fruit and other plant foods Z Ernahrungswiss. 35(4):348-55 1996
PUBMED ID:
9000332 |
[888] |
|
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